WebThere are six nuclear PML isoforms designated PMLI to PMLVI and one cytoplasmic isoform, PMLVIIb (called PMLVII in some publications) (Figure 1 B) ( Jensen et al., 2001 ). … WebJan 10, 2024 · It is well recognized that promyelocytic leukemia (PML) proteins are scaffold molecules of PML-nuclear bodies (PML-NBs) in the nucleus and the generation of chimera proteins, PML-retinoic acid receptor α (PML-RARα), is involved in the pathogenesis of acute promyelocytic leukemia (APL) (de The et al. 2012; Shen et al. 2004 ).
PML isoforms: a molecular basis for PML pleiotropic functions
WebJan 4, 2016 · The PML NB core is made of PML protein isoforms, which diverge in the C terminus because of alternative splicing (Bernardi and Pandolfi, 2007), and we found that PML isoform II (PML-II) plays a critical role in nuclear LD formation. The involvement of PML-II, however, was evident only in limited types of cells in which PML-II was targeted to ... WebFeb 1, 2024 · PML is a stress-responsive protein that coordinates assembly of phase-separated nuclear aggregates, known as PML nuclear bodies (PML-NBs), where a large number of protein interactors and... hamachi multiplayer games
Frontiers Differential Roles of PML Isoforms
WebThe National Library of Medicine (NLM), on the NIH campus in Bethesda, Maryland, is the world's largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. WebMay 22, 2013 · Promyelocytic leukemia proteins (PMLs) are proapoptotic molecules involved in cell proliferation, senescence, and tumor suppression [1,2]. The human PML family comprises six nuclear isotypes... WebNov 2, 2024 · PML Antibody (E-11) is a mouse monoclonal IgG 1 κ PML antibody, cited in 20 publications, provided at 200 µg/ml; specific for an epitope mapping between amino acids 27-63 near the N-terminus of PML of human origin; PML Antibody (E-11) is recommended for detection of all isoforms of PML of mouse, rat and human origin by WB, IP, IF, IHC(P) … hamachi minecraft port