Hsf2 testis

Author: wdnr

August undefined, 2024

Web11 jan. 2024 · Heat shock factor 2 (HSF2), a transcription factor, plays significant roles in corticogenesis and spermatogenesis by regulating various target genes and signaling pathways. However, its expression, clinical significance and correlation with tumor-infiltrating immune cells across cancers have rarely been explored. In the present study, we … Web7 jan. 2016 · The phenotype of Hsf2-KO in spermatogenesis is controversial. Hsf2-KO mice exhibit reduced testis and epididymis sizes, vacuolization of the seminiferous tubules, and lower sperm counts (Kallio et al. 2002; Wang et al. 2003). Kallio et al. reported that spermatocytes are eliminated via stage-specific apoptosis at the pachytene …

Novel testis-specific protein that interacts with heat shock factor 2

WebIn the present study, we investigate selective cell loss from cryptorchid rat testis by using DNA flow cytometry and by determining protein and mRNA expression of Hsf1, Hsf2, … Web1 apr. 2011 · Collectively, down-regulated DDX3Y, HSF2, Sly, and Ssty2 in the testis might be the mechanism responsible for the MEQ-induced inhibition of spermatogenesis and ultrastructural changes in sperm.... peterson orthovirginia

HSF2BP Gene - GeneCards HSF2B Protein HSF2B …

Web14 okt. 2012 · It was reported that HSPA2, a well-defined target of HSF2, was highly expressed in human testis and appeared to have an essential role during the meiotic phase of spermatogenesis according to Son et al. ( 1999 ). Homologous HSPA2 -related genes had been identified in germ cells from mammals, birds, amphibians and fish (Eddy 1999 ). WebIn adult testis, HSF2 mRNA is found at highest levels in spermatocytes and round spermatids. Immunocytochemical staining and gel mobility shift analysis demonstrate … star stable accounts that work

Heat Shock Transcription Factor 1 Localizes to Sex …

A dominant-negative mutation of HSF2 associated with idiopathic ...

Web1 mrt. 2011 · Surgery-induced cryptorchidism, in which the testes are prevented from descending into the scrotal sac, results in testicular germ cell death, and it is commonly … Web3 jul. 1998 · We screened a human testis cDNA library for proteins that can associate with HSF2 by the yeast two-hybrid system, and isolated clones encoding a novel protein, designated HSF2 binding protein (HSF2BP), that associates with HSF2 in vitro and in vivo and is specifically expressed in testis. star stable bug twitterWebNumerous apoptotic spermatocytes are also observed at this time point. These results suggest that the Hsf1/Phlda1 pathway plays an important role in the apoptosis of primary spermatocytes in cryptorchid testis. We present evidence suggesting that Hsf2 is also involved in germ cell removal in cryptorchid testis. Mol. Reprod. star stable age rating

"Web12 aug. 2008 · ChIP analysis of HSF2-binding (HSF2) on six target promoters in WT testis, brain, muscle, and kidney. Nonspecific antibody (NS) was used as a negative control, … " - Hsf2 testis

Hsf2 testis

Expression of heat shock factor 2 in mouse testis: potential role as …

WebHSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that … WebHSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses.

Did you know?

Web12 aug. 2008 · HSF2 was also found to regulate the transcription of MSYq resident genes, whose transcriptional regulation has been unknown. Importantly, disruption of Hsf2 … Web3 jul. 1998 · Although heat shock factor 2 (HSF2) binds to heat shock element (HSE) constitutively during differentiation, development and spermatogenesis, little is known about the nature and mechanism of transcriptional control of heat shock genes by HSF2.We screened a human testis cDNA library for proteins that can associate with HSF2 by the …

Web10 jan. 2024 · Heat shock response gene expression is unaltered in cryptorchid testis Thermosensitive genes are essential for organism to survive exposure to stress [ 16, 17 ]. The human heat shock family genes are HSF1, HSF2, HSF4, HSF5, HSFY2, and HSFX2 [ … Web1 nov. 2010 · We investigated the effect of H2-GMZ on HSF1 expression and regulation of chaperons HSP90beta, HSP70-3, CDC37 and IL-1alpha (a known disrupting factor for …

Web1 mrt. 2011 · Surgery-induced cryptorchidism, in which the testes are prevented from descending into the scrotal sac, results in testicular germ cell death, and it is commonly used as an experimental tool in the s... WebIn testis, HSF2 was shown to regulate the expression of HSPs and Y chromosomal multi-copy genes, including SSTY2, SLY, and SLX, which have critical functions in determining …

Web21 mrt. 2024 · HSF2BP (Heat Shock Transcription Factor 2 Binding Protein) is a Protein Coding gene. Diseases associated with HSF2BP include Premature Ovarian Failure 19 . …

Web9 jun. 2024 · Abstract. Heat shock factor 2 (HSF2) regulates the transcription of the male-specific region of the mouse Y chromosome long arm (MSYq) multicopy genes only in … star stable antheia horseWebHSF2 protein expression summary. The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-s hock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. star stable a horse gameWebHere, we show that HSF1 is transiently expressed in meiotic spermatocytes and haploid round spermatids in mouse testis. The Hsf1−/− male mice displayed regions of seminiferous tubules containing only spermatogonia … star stable catherine\u0027s memories golden hillsWeb21 mrt. 2024 · HSF2 (Heat Shock Transcription Factor 2) is a Protein Coding gene. Diseases associated with HSF2 include Spermatogenic Failure 10 and Erythroleukemia . … peterson outfitters llcWeboccupied by HSF2 in other tissues, we analyzed the HSF2 binding in testis, brain, muscle, and kidney. The ChIP analyses showed that the target promoters were occupied by HSF2 only in testis (Fig. 1C), indicating that the promoter sequence alone is not sufficient to specify HSF2 binding. As supporting evidence, peterson outdoors ministryWebAnalysis of HSF2-binding (HSF2) on the six selected promoters, in addition to three nontarget promoters for HSF2: Hsp25. 1, Fyn, and Spata 2. (C) Target genes are … star stable catherine\u0027s memories silvergladeWebC) Target genes are occupied by HSF2 only in testis. ChIP analysis of HSF2-binding (HSF2)onsixtargetpromotersinWTtestis,brain,muscle,andkidney.Nonspeciﬁcantibody(NS)wasusedasanegativecontrol,andacetylatedhistone4antibody … peterson owa webmail