Cryptophycin 中文
WebJan 16, 2024 · 隐霉素1(100nm;1-7min)显著降低微管缩短和生长的速率和范围,并显著增加衰减或暂停阶段的持续时间 [2]。. 细胞凋亡分析 [1]细胞系:SKOV3细胞浓度:50pm孵育时间:4h结果:引起细胞迅速萎缩,失去正常的椭圆球体形状,形成膜泡。. 细胞周期分析 [1]细胞系:MDA ...
Cryptophycin 中文
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WebDec 15, 2006 · Cryptophycin 1 is a remarkably potent antiproliferative compd. that shows excellent antitumor activity against mammary, colon, and pancreatic adenocarcinomas in … WebFeb 15, 2015 · Cryptophycin. Antibody drug conjugates (ADCs) are currently an emerging class of treatment for targeted therapies against cancer.1, 2, 3, 4 ADCs consist of an …
WebCryptophycin is the cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity … WebCryptophycin is a new anticancer drug discovered from micro-algae by researchers of the University of Hawaii and Wayne State University. Some of the cryptophycin analogs are …
WebCryptophycin 1 is a natural product that was initially isolated from blue-green algae which has shown potent broad spectrum antitumor activity in preclinical in vitro and in vivo models. The drug strongly binds to tubulin and disrupts microtubule assembly for more than 24 hours after its removal. We evaluated cell survival, intracellular levels and inhibition of … Cryptophycins are potent microtubule inhibitors, with a mechanism of action similar to that of vinca alkaloids. Treatment of cells with cryptophycins depletes microtubules through interaction with tubulin, thereby preventing cell division. Cryptophycins are capable of inducing apoptosis, possibly … See more Cryptophycins are a family of macrolide molecules that are potent cytotoxins and have been studied for potential antiproliferative properties useful in developing chemotherapy. They are members of the See more Cryptophycins were originally discovered in 1990 in cyanobacteria of the genus Nostoc. Cryptophycins were patented as antifungal agents … See more Cryptophycins were first isolated from cyanobacteria but have subsequently been produced by chemical synthesis. Chemoenzymatic … See more Members of the cryptophycin family have been studied as anti-tumor agents. Cryptophycin-52, a synthetic analog of natural product cryptophycins also known as LY355703, reached See more
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WebJun 17, 2024 · Methods: A peptide-drug conjugate (ER-472) composed of Cltx linked to cryptophycin as warhead was developed as a tool to probe the molecular target and mechanism of action of Cltx, using multiple xenograft models. Results: Neuropilin-1 (NRP1), an endocytic receptor on tumor and endothelial cells, was identified as a novel Cltx target, … scotland\\u0027s finance ministerWebApr 8, 2005 · Abstract. Cryptophycin is a promising drug in many cancer therapies. Unfortunately, cryptophycin is expensive to produce synthetically because of its complex structure; however, certain strains of micro-algae naturally produce cryptophycin. This work studies the production of cryptophycin from two strains of Nostoc sp., ATCC 53789 and … scotland\\u0027s finance secretaryWebAug 1, 2024 · Cryptophycin-52 (CR52), a tubulin inhibitor, exhibits promising antitumor activity in vitro (picomolar level) and in mouse xenograft models. However, the narrow … premier inn reading centreWeb中文名称 念珠藻素 英文名称 cryptophycin 定 义 从念珠藻(Nostoc)分离的一种多肽,有抗肿瘤作用。 应用学科 海洋科技(一级学科),海洋技术(二级学科),海洋生物技术(三 … scotland\\u0027s financial health serviceWeb念珠藻素. "cryptophytas" 中文翻譯: n. [植] 隱藻門. "cryptophyceaes" 中文翻譯: n. [植] 隱藻綱. "cryptopidae" 中文翻譯: n. 【昆蟲】盲蜈蚣科. "cryptophthalmus-syndactyly … scotland\\u0027s financial schoolsWebMar 1, 2002 · Cryptophycin-1 is a cyanotoxin produced by filamentous cyanobacteria. It has been evaluated as an anticancer agent with great potential. premier inn rayleigh essexWebSep 21, 2024 · The in vitro cytotoxic activity of the RGD–cryptophycin conjugates was tested against the α v β 3 integrin expressing M21 human melanoma cells. 53, 54 Cell viability was measured by resazurin assay after 2 h treatment with increasing concentrations of the free drug and conjugates 1 and 2 in the absence or presence of β-glucuronidase (2 U ... scotland\u0027s financial schools