Clofarabine late effects
WebIn particular, four of 96 patients evidenced capillary leak syndrome (pleural and pericardial effusions) or systemic inflammation response syndrome, which is characterized by tachycardia, hypotension, and pulmonary edema. Clofarabine administration was discontinued for these patients. WebFeb 1, 2005 · No dose escalation of clofarabine beyond 40 mg/m 2 per day, the established MTD for single-agent phase 2 studies, was considered. Cycles were repeated every 3 to 5 weeks as indicated by leukemia recurrence and recovery of normal hematopoiesis.
Clofarabine late effects
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WebFeb 25, 2024 · Anticancer drug-induced CLS has a variable incidence depending on the diagnostic criteria used and the specific drug studied, varying from case reports under gemcitabine treatment10,15, 16, 17, 18, 19, 20, 21, 22to a universal risk of severe capillary leak with rituximab in chronic lymphocytic leukemia when the lymphocyte count is >50 × …
WebDec 19, 2024 · Abstract. Cancer therapy–related cardiac dysfunction (CTRCD) is one of the most concerning cardiovascular side effects of cancer treatment. Important reviews within the field of cardio-oncology have described various agents to be associated with a high risk of CTRCD, including mitomycin C, ifosfamide, vincristine, cyclophosphamide, and … WebOct 17, 2024 · Common side effects include bone marrow suppression, leucopenia, infections, fever, nausea, vomiting, anorexia, diarrhea, headache, fatigue, mucositis and skin rash. Clofarabine has been …
WebClofarabine [Clofarex] is a purine nucleoside in development with Bio-envision, the Southern Research Institute and ILEX Oncology as an anticancer agent. Clofarabine's nucleoside structure is such that both the purine and ribose rings are halogenated, which allows it to inhibit DNA synthesis at two … WebSide effects included neutropenia in all patients. Recurring but sporadic toxicities included prolonged neutropenia, severe vomiting, and bacterial infections. Conclusion: …
WebClofarabine is approved to treat: Acute lymphoblastic leukemia that has recurred (come back) or is refractory (does not respond to treatment) in children and young adults aged 1 to 21 years who have already had at least two other types of treatment. Clofarabine is …
WebAug 2, 2024 · Common side effects of clofarabine may include: fever, chills, or other signs of infection; stomach pain, nausea, vomiting, loss of appetite, diarrhea; fast heartbeats; nosebleeds, bruising; pain in your arms or legs; headache, feeling tired; itching or skin rash; or low blood pressure. toy boxing beltsWebOct 1, 2006 · Furthermore, clofarabine's side-effect profile is typically manageable and tolerable. Future studies with clofarabine include single-agent studies in solid tumours, … toy boxes with shelves for kidsWebPossible Side Effects Diarrhea Abdominal pain Hand-foot syndrome (tingling of the hands and feet, redness and flaking of the skin) Rash Flushing of the skin Itching Fast … toy boxingWebWell-tolerated doses of clofarabine induced complete remission in all treated animals (n = 12) suffering from both early- and late-stage disease. We further took advantage of … toy boxing ring• Tumor lysis syndrome (TLS). Clofarabine quickly kills leukaemia cells in the blood. The body may react to this. Signs include hyperkalemia, hyperuricemia, and hyperphosphatemia. TLS is very serious and can lead to death if it is not treated right away. • Systemic inflammatory response syndrome (SIRS): symptoms include fast breathing, fast heartbeat, low blood pressure, and fluid in the lungs. toy boxes with wheelsWebalkalinize urine throughout the 5 days of Clolar administration to reduce the effects of tumor lysis and other adverse events. Discontinue Clolar if hypotension develops during the 5 days of administration. Monitor renal and hepatic function during the 5 days of Clolar administration [see . Warnings and Precautions (5.6, 5.7)]. toy boy 100 mlWebClofarabine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: nausea vomiting stomach pain diarrhea constipation loss of appetite … toy boy 2 assistir