WebCitrinin (Figure 5 (b)) is a low-molecular-weight (250.25 g mol −1) compound that has a melting point of 175 °C. Citrinin initially was named as monascidin A and was regarded … WebJan 10, 2024 · Marine-derived fungi are known as a rich source of various bioactive metabolites with high range of chemical diversity. In the course of our ongoing …
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WebCitrinin is one of the mycotoxins produced by Penicillium citrinum. We examined the decomposition products after heating citrinin in water at 140 degrees C and isolated a major product, citrinin H2 (3- (3,5-dihydroxy-2-methylphenyl)-2-formyloxy-butane). Citrinin H2 did not show significant cytotoxicity to HeLa cells up to a concentration of 200 ... WebCitrinin C13H14O5 CID 54680783 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. …
WebMay 15, 2024 · Citrinin H1 and H2 are degradation products of citrinin that are formed by boiling citrinin solution. Approximately 5 µL of degraded citrinin solution (10 pmol/µl) was required for visual detection of citrinin with our minimum recommended amount as opposed to only 1 µL untreated citrinin solution (10 pmol/µl) (Fig. S8, SI). WebJan 2015. James Doughari Hamuel. Citrinin is a nephrotoxic mycotoxin produced by several fungal strains belonging to the genera Penicillium, Aspergillus and Monascus. It contaminates various ...
Webdouble strand H0−H1 structure. Because of the complemen-tary sequences between H1 and H2, strand displacement occurs as soon as the double strand H0−H1 is formed. Therefore, the HCR can generate a large amount of double-stranded DNA (H1−H2) after an initiation by the ssDNA barcode (Figure S1). The dsDNA (H1−H2) is designed to Citrinin H1 is produced out of two citrinin molecules and its toxicity is increased compared to the original toxicity of citrinin. Citrinin H2, a formylated derivative of phenol A, is less toxic than citrinin. Phenol A seems to be produced mainly under acidic conditions. Dicitrinin A is a dimer of citrinin molecules … See more Citrinin is a mycotoxin which is often found in food. It is a secondary metabolite produced by fungi that contaminates long-stored food and it causes different toxic effects, like nephrotoxic, hepatotoxic and cytotoxic effects. … See more Citrinin was one of the many mycotoxins discovered by H. Raistrick and A.C. Hetherington in the 1930s. In 1941 H. Raistrick and G. Smith identified citrinin to have a broad antibacterial activity. After this discovery the interest in citrinin rose. However, in 1946 … See more The existing information on occurrence of citrinin in food suggests that relatively high citrinin concentrations can be found in stored grains and … See more Citrinin is biosynthesized by fungi species of Penicillium, Monascus and Aspergillus. For the production of citrinin, a minimal set of genes is needed. These genes are conserved in most … See more Citrinin is a polyketide mycotoxin, which is a secondary metabolite of some fungi species. Its IUPAC name is (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid and the molecular formula is C13H14O5. Citrinin has a … See more There are different types of toxicity. The types of toxicity that have been studied for citrinin are acute toxicity, nephrotoxicity, genotoxicity See more Various in vitro studies have revealed the involvement of citrinin toxicity in reduced cytokine production, inhibition of RNA and DNA synthesis, induction of oxidative stress, inhibition of nitride oxide gene expression, increase in ROS production and activation of … See more
WebAug 19, 2010 · However, citrinin H1, as a dimeric product formed upon heating at 140 • C in the presence of water, contributed to an increase in cytotoxicity [5]. Despite its toxic …
WebJan 10, 2024 · Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus … boilermaker course in fet collegesWebOct 9, 2024 · Citrinoids are BQs associated with the citrinin (33) biosynthetic pathway and include citrinin H1 (34) and its stereoisomer 1-epi-citrinin H1. Citrinin (33) itself is not a quinone, but citrinin H1 (34) can be synthesized by heating molecules of citrinin in water (Trivedi et al. 1993) and has also been discovered in P. citrinum (section Citrina ... gloucestershire v northamptonshireWebJan 1, 2008 · However, Citrinin H1, another identified product of citrinin pyrolysis, also formed and is tenfold more toxic than citrinin (on a weight basis; Bentrivedi et al. 1993). γ-Aminobutyric acid Because the crude extract of MFR could alleviate hypertension in rats, a systematic fractionation and isolation of the responsible bioactive compound was ... gloucestershire v kent youtubeWebThe toxic compound was isolated from heated citrinin and its structure was determined. Its toxicity, evaluated by cytotoxicity assay, was 10-fold higher on a weight basis than that of citrinin. This new compound was named citrinin H1, which was also formed by heating citrinin at 100 °C for 30 min. boilermaker courses in durbanWebJan 23, 2024 · Chemical structures of citrinin and its decomposition products citrinin H1 and citrinin H2. CIT is synthesized via the polyketide pathway [20]. It is generally known that three . gloucestershire voluntary allianceWebSep 17, 2013 · Open in a separate window. Penicillium citrinum is one of the commonest microfungi on Earth, occurring in all kinds of food and feed, in almost all climates. CIT is produced over the range of 15–30 °C and optimally at 30 °C. Penicillium expansum is known as a postharvest pathogen of fruits (e.g., apple) and vegetables. boilermaker courses in rustenburgWebJan 1, 2015 · citrinin H1, from citrinin on mild heating in water. Journal of the Chemical . Society Perkin Transactions 1: 2167-2171. 23. Clark BR, … boilermaker courses in gauteng