Cisplatin-induced nephrotoxicity

WebFig. 2: The mechanism summary of cisplatin-induced nephrotoxicity. The mechanisms mainly include the transport and metabolism of cisplatin, apoptosis, autophagy, DNA … WebThe major side effect of cisplatin is renal damage. Persea americana has been used in the Indian system of medicine to treat various diseases. This study aims to investigate the …

Protective effect of magnesium preloading on cisplatin-induced …

WebCisplatin toxicity arises most characteristically in the kidneys, cochlea, bone marrow, gastrointestinal mucosa and nerves (with altered taste, peripheral neuropathy and encephalopathy). The kidneys are particularly susceptible to cisplatin toxicity, as they are almost exclusively responsible for its excretion. WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … canon pixma ts7451 einrichten https://martinwilliamjones.com

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

WebApr 24, 2024 · Cisplatin, a platinum-based antineoplastic agent, is the cornerstone for the treatment of many malignancies. Nephrotoxicity is the primary dose-limiting toxicity, and various hydration regimens and supplementation strategies are used to prevent cisplatin-induced kidney injury. WebResults: The incidence of nephrotoxicity was 23.7% overall, with 8.1% of patients developing cisplatin-induced nephrotoxicity after the first dose. Patients who … WebJun 21, 2024 · The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk... canon pixma ts7451 bewertung

Cisplatin nephrotoxicity: new insights and therapeutic implications

Category:Activation and involvement of p53 in cisplatin-induced nephrotoxicity

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Cisplatin-induced nephrotoxicity

Cisplatin nephrotoxicity as a model of chronic kidney disease

WebNational Center for Biotechnology Information WebOct 3, 2016 · Nephrotoxicity is one of the major and most serious toxicities caused by cisplatin and is known to be its dose-limiting toxicity [ 1 ]. Cisplatin-induced nephrotoxicity (CIN) occurs in 30–40 % of patients receiving cisplatin and is recognized to be cumulative, dose related, and usually reversible [ 2, 3 ].

Cisplatin-induced nephrotoxicity

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WebCisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. In particular, cisplatin is nephrotoxic and can cause acute kidney injury and chronic kidney disease. Preclinical studies have provided insights into the cellular … WebAug 6, 2014 · The use of cisplatin is frequently limited by various significant side effects such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity. After a single dose of cisplatin (50–100 mg/m2), approximately one-third of the patients develop nephrotoxicity [10, 11].

WebApr 15, 2024 · Eventually, nephrotoxicity complicated by hypomagnesaemia was confirmed, and cisplatin-induced nephrotoxicity led to the final diagnosis of a familial … WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose …

WebJun 1, 2024 · Cisplatin (CP) nephrotoxicity is a severe renal complication in patients receiving CP-based chemotherapy, but the incidence of AKI following CP chemotherapy …

WebJun 22, 2024 · Cisplatin (CisP) is a chemotherapeutic agent used to treat head and neck and lung cancer in adults and over 15 different pediatric cancers. Despite its known … canon pixma ts7451 testberichtWebDive into the research topics of 'Ethanol extract of Crataeva nurvala stem bark reverses cisplatin-induced nephrotoxicity'. Together they form a unique fingerprint. … canon pixma ts7451 treiberWebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … flagstone farm cotswoldsWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … flagstone fire pit ideasWebBoldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3 canon pixma ts8050 inkjet printerWebFeb 15, 2024 · We then examined GSDME cleavage in a cisplatin-induced mouse model of nephrotoxicity and found that cisplatin increased serum creatinine and BUN (Fig. 1 E, F). HE staining exhibited severe... canon pixma ts7451 multifunktionsdrucker testWebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. flagstone fire pit area