Cancer testis antigens
WebSep 25, 2006 · Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. WebAug 28, 2010 · Melanoma antigen-1 (MAGE-1), synovial sarcoma X breakpoint-1 (SSX-1) and cancer-testis-associated protein of 11 kDa (CTp11) antigens have been designated as cancer-testis antigens (CTA). It has been reported that MAGE-1 and SSX-1 mRNA are expressed with a high percentage and specificity in HCC[ 16 , 18 - 20 ].
Cancer testis antigens
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WebJan 1, 2024 · A gene is generally considered to be a CG antigen if it is expressed in the gametogenic cells of the testis or ovary (including fetal ovary) and in some proportion of human cancers, but is expressed in two or fewer normal somatic tissues. CG antigen genes are also commonly expressed in trophoblast tissue. CG antigens were originally … WebApr 12, 2024 · As an ERG target gene, TDRD1 might play an important role in human prostate cancer development, and as a cancer/testis antigen, TDRD1 might have long …
WebCancer-testis antigens (CTA), such as NY-ESO-1, MAGE-A1, and MAGE-A3, are immunogenic proteins encoded by genes, which are normally expressed only in male germ cells but are activated by ill-defined epigenetic mechanisms in human tumors, including lung cancers. Previously, we reported induction of these CTAs in cancer cells, but not normal ... WebCancer/testis antigens (CTAs) are considered ideal targets for cancer treatment due to their high immunogenic, restricted expression in germ cells and malignancies. 7–9 Generally, germ cells do not express human leukocyte antigen (HLA) class I molecules, leading them escape from the attack of T cells. Though somatic tissues, such as thyroid ...
WebJul 31, 2024 · Cancer-testis antigens (CTAs) are tumour-associated antigens that have garnered strong attention as potential clinical biomarkers in targeted immunotherapy due to their cancer-restricted expressions and robust immunogenicity. Previous clinical studies reported that CTAs correlated with negative hormonal status, advanced tumour … WebMaterial and methods: In the present study, we evaluated expression of seven cancer-testis antigens (CTAs) that are regarded as putative biomarkers and immunotherapeutic targets along with NMP22 in urinary exosomes of bladder cancer patients, healthy subjects and patients affected with nonmalignant urinary disorders.
WebApr 13, 2024 · Tumor cells also present antigens derived from overexpressed self-peptides, cancer/testis antigens, somatic variants, splicing variants, endogenous retroelements, alternative protein processing, and likely other sources as well as mHAs. 41-44 It may be necessary to account for these components of the HLA-peptidome to uncover …
WebApr 13, 2024 · Tumor cells also present antigens derived from overexpressed self-peptides, cancer/testis antigens, somatic variants, splicing variants, endogenous retroelements, … speed food recipes slimming worldWebCancer/testis antigens (CTAs) are a group of tumor antigens expressed in numerous cancer tissues, as well as in the testis and placental tissues. There are over 200 CTAs … speed food on slimming worldWeb10 rows · Cancer-testis antigens have restricted expression pattern. In normal tissue, the expression is ... speed foodsWebFeb 5, 2024 · Preferentially expressed antigen in melanoma (PRAME), which belongs to the cancer/testis antigen (CTA) gene family, plays a pivotal role in multiple cellular processes and immunotherapy response in human cancers. PRAME is highly expressed in different types of cancers and is involved in cell proliferation, apoptosis, differentiation … speed foot enterprise co. ltdCancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a … See more With the development of tumor-associated antigens (TAA), the first clone of a human tumor antigen, melanoma antigen-1 (MAGE-1) was reported in 1990s, which elicited an autologous cytotoxic T-lymphocyte (CTL) … See more Germ cells share some features with cancers. The motile and penetrating features and colonization of primitive germ cells resemble the migration of cancer cells from primary … See more CT antigens can be divided by whether they are encoded on the X chromosome (X-CT antigens genes) or not (non-X-CT antigens genes). It has been estimated that 10% of genes … See more The expression of CT antigens genes are exclusively regulated by epigenetic events both in normal and cancer tissues, while DNA methylation and histone post-translational … See more Immunogenicity In normal tissues, CT antigens are exclusively expressed in testis, making it no access to the … See more speed food méruWebOct 5, 2008 · The targets, cancer-testis (CT) antigens, are immunogenic proteins preferentially expressed in normal gametogenic tissues and different histological types of tumors. Therapeutic cancer vaccines directed against CT antigens are currently in late-stage clinical trials testing whether they can delay or prevent recurrence of lung cancer … speed foods slimming world 2021WebOf all the tumor-associated antigens, cancer/testis antigens (CTAs) are of particular interest as a potential target for immunotherapy because of their strong in vivo immunogenicity and unique expression patterns. 3. CTAs belong to a group of proteins that are expressed in the developing embryo, ... speed food slimming world